The milestone, reached with a second straight NASCAR Cup Series victory, helped cement his status as one of the premier drivers of the past 20 years.
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Joey Logano finished second, while Brad Keselowski earned third despite a slow start.
Busch became the first driver in the 2019 season with more than one race victory.
Auto Club 400: 2019 winner, order of finish for top 20
Lead changes: 17
Cautions: 4
Sporting News provided live coverage throughout the race. Here’s how Busch won:
NASCAR at California: Highlights from Auto Club 400
(All times Eastern)
6:38 p.m. — Kyle Busch does it! National series win No. 200 for one of NASCAR’s best modern drivers.
6:32 p.m. — Ten more laps. It’s still all Kyle Busch.
6:28 p.m. — With 15 laps to go, it’s Kyle Busch, Logano and Keselowski atop the leaderboard.
6:22 p.m. — Kyle Busch is back in first.
6:17 p.m. — We’re back to green with 31 laps to go.
6:08 p.m. — Caution. Bubba Wallace has a major tire failure amid green-flag pit stops, helping Kyle Busch, who hadn’t pitted yet.
5:58 p.m. — There are 50 laps remaining and Keselowski still has a narrow edge over Logano (second) and Harvick (third). Kyle Busch is in sixth place following his speeding penalty earlier in the final stage.
5:43 p.m. — That Kyle Busch error really opens things up for others. Right now, Keselowski is in first place, and Kevin Harvick has slid into second.
5:37 p.m. — Kyle Busch takes a speeding penalty.
5:30 p.m. — Kyle Busch wins Stage 2! He now has two stage wins this afternoon and is well-positioned to sweep the race.
5:15 p.m. — We’re exactly halfway through the Auto Club 400. Kyle Busch is in first, followed by Keselowski and Erik Jones.
5:03 p.m. — Brad Keselowski struggled in the early going, but he’s up to third.
4:56 p.m. — And Kyle Busch retakes the lead moments later. He’s led 55 of the 75 laps thus far.
4:54 p.m. — Joey Logano jumps up to first place.
4:48 p.m. — Truex Jr. apparently had some rear damage from the stage-closing accident as well.
4:40 p.m. — Here’s a look at that Stenhouse incident.
4:36 p.m. — Crazy end to Stage 1! Kyle Busch wins it and Stenhouse spins out. Kyle Larson also took damage.
4:30 p.m. — Caution for Austin Dillon. His rear right tire went out.
4:13 p.m. — William Byron takes the lead midway through Stage 1.
4:03 p.m. — Kyle Busch has moved to the front. He’s going for his 200th career win.
3:57 p.m. — Ten laps in, Hamlin leads the way. Aric Almirola is in second place, and Kyle Busch is in third. Stenhouse runs fifth.
3:44 p.m. — And we’re off!