Here is a look at each team as they battle for a spot in the Final Four on April 2 in Houston. Game time: 6:09 p.m. ET on TBS, played in Chicago.
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Virginia Cavaliers (29-7)
No. 1 seed, Midwest Region
Coach: Tony Bennett (seventh season)
Bid: At-large, ACC
Starting lineup
F Anthony Gill (13.9 ppg, 6.2 rpg)
F Isaiah Wilkins (4.8 ppg, 4.1 rpg)
G Malcolm Brogdon (18.4 ppg, 4.0 rpg)
G Devon Hall (4.4 ppg, 2.6 rpg)
G London Perrantes (10.8 ppg, 3.0 rpg)
Storylines:
— The Cavaliers have won all three of their tournament games by at least eight points and have yet to trail in a second half.
— Virginia won its only meeting of the regular season against Syracuse 73-65, on the strength of Brogdon’s 21 points.
— The Cavaliers haven’t been to a Final Four since 1984.
Syracuse Orange (22-13)
No. 10 seed, Midwest Region
Coach: Jim Boeheim (40th season)
Bid: At-large, ACC
Starting lineup:
G Trevor Cooney (12.8 ppg, 2.5 rpg)
G Malachi Richardson (13.0 ppg, 4.2 rpg)
G Michael Gbinije (17.8 ppg, 4.1 rpg)
F Tyler Roberson (9.0 ppg, 8.5 rpg)
C DaJuan Coleman (5.0 ppg, 4.6 rpg)
Storylines:
— Under Boeheim, Syracuse has reached the regional finals eight times, with its last appearance in 2013.
— Gbinije has scored 23 and 20 points in his last two games and is averaging 17.8 ppg in the tournament.